The Secrier lab at the UCL Genetics Institute
works at the
interface of genomics and immunology. Our main research focus is cancer, and in this arena we are interested in understanding the mutational processes underlying cancer development and the cell state transitions that enable progression to advanced malignancy.
We also explore the role of the tumour microenvironment in this process by integrating bulk, single cell and digital pathology data.
To address these questions, we are developing new computational methods for linking multi-omics data, and apply machine learning and deep learning methodology to identify genomic triggers of phenotypes such as dormancy or EMT.
The lab has recently been awarded a UKRI Future Leaders Fellowship
to explore the mutational processes and spatial context of tumour dormancy.