The Secrier lab at the UCL Genetics Institute
works at the
interface of genomics and immunology. Our main research focus is cancer, and in this arena we are interested in understanding the evolution of genomic
instability during cancer development and progression, and how this links to changes in the tumour microenvironment
and impacts immune responses. We aim to address this by developing new computational methods for the identification
of large-scale events contributing to genomic instability, probabilistic models that link genetic changes and immune activity,
and methods for inferring the timing and genetic features of key points in cancer progression. We have also recently started
to explore genetic factors linked to risk and progression in neurodegenerative diseases.